Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
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Year : 2010  |  Volume : 5  |  Issue : 1  |  Page : 55-56
Author's reply

College of Medicine, King Abdulaziz University Jeddah, Saudi Arabia

Date of Web Publication15-Jan-2010

Correspondence Address:
Siraj Wali
College of Medicine, King Abdulaziz University Jeddah
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

PMID: 20351966

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How to cite this article:
Wali S. Author's reply. Ann Thorac Med 2010;5:55-6

How to cite this URL:
Wali S. Author's reply. Ann Thorac Med [serial online] 2010 [cited 2023 Feb 1];5:55-6. Available from:

Dear Editor;

First, I would like to thank the author for his comment regarding the case report of Mycobacterium chelonae empiema with bronchopleural fistula in an immunocompetent patient. I totally agree with his comment. Our patient may well have had MSMD, however, I wish there is a screening test for Interferon gamma receptor deficiencies. Diagnosis MSMD is established by flow cytometric evaluation of cell surface receptor expression on monocytes and lymphocytes as well as examining signaling either by intracellular staining (lack of STAT1 phosphorylation in response to IFN-gamma) or western blot. Detection of the mutation at the molecular level confirms the diagnosis. In my view, tell a screening test is available such cases will continue to be missed since not all institutions are capable of running the diagnostic test.


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