| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 5
| Issue : 2 | Page : 86-91 |
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Sarcoidosis-associated pulmonary hypertension: Clinical features and outcomes in Arab patients
Esam H Alhamad1, Majdy M Idrees2, Mohammed O Alanezi3, Ahmad A AlBoukai4, Shaffi Ahmad Shaik5
1 Department of Medicine, Pulmonary Division, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
2 Department of Medicine, Pulmonary Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia
3 Department of Medicine, Pulmonary Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia
4 Radiology and Medical Imaging, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
5 Family and Community Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
Correspondence Address:
Esam H Alhamad
Department of Medicine, Division of Pulmonary Medicine, King Khalid University Hospital, King Saud University, P.O. Box 18321, Riyadh 11415
Saudi Arabia
 Source of Support: None, Conflict of Interest: This study was not externally funded and no author has any conflict of interest to disclose  | Check |
DOI: 10.4103/1817-1737.62471
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Background : Pulmonary hypertension (PH) occurs in many patients with interstitial lung disease, including sarcoidosis. We explored the frequency, clinical characteristics and outcomes of PH in Arab patients diagnosed with pulmonary sarcoidosis.
Methods : A retrospective study in three tertiary hospitals was performed on 96 patients who underwent Doppler echocardiography. Demographic and clinical characteristics, physiological studies and computed tomography (CT) results were collected, and compared between patients with and without PH.
Results : Twenty (20.8%) patients were found to have PH. Patients with PH were more likely to be symptomatic (cough, P = 0.008; dyspnea, P = 0.04), to have an advanced radiographic stage (P = 0.001), and to be receiving systemic therapy (P = 0.001), compared to those without PH. Physiological data including pulmonary function test parameters, arterial blood gas levels and oxygen saturation at rest and after exercise were all significantly lower in patients with PH compared to those without PH. Comparison of CT patterns between patients with and without PH showed significant differences in the frequencies of ground-glass opacity (61.5 vs. 28.8%, P = 0.032) and fibrosis (76.9 vs. 44.2%, P = 0.035). In total, four patients died during the study period, including three with evidence of PH.
Conclusions : The frequency of PH in the present study was 20.8%. Clinical, physiologic and radiographic characteristics appeared to differentiate patients with PH from those without PH. The presence of PH contributed to poor outcomes in patients with pulmonary sarcoidosis. |
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