Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
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Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 129
Author reply

Pembe Kosk Sok. Emek apt. No: 16 D:14 34732 Kadikoy, Istanbul, Turkey

Date of Web Publication30-Mar-2013

Correspondence Address:
Benan Caglayan
Pembe Kosk Sok. Emek apt. No: 16 D:14 34732 Kadikoy, Istanbul
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Source of Support: None, Conflict of Interest: None

PMID: 23741281

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How to cite this article:
Caglayan B. Author reply. Ann Thorac Med 2013;8:129

How to cite this URL:
Caglayan B. Author reply. Ann Thorac Med [serial online] 2013 [cited 2023 Feb 6];8:129. Available from:


We thank Dr. Mehta and colleagues for their letter [1] in response to our recent article published in the Annals of Thoracic Medicine. [2] As they indicate, our article addressed the issue about the determination the etiology and prevalence of malignancy for hypermetabolic and enlarged hilar/mediastinal lymph nodes in patients with previously diagnosed extra pulmonary malignancy. EUS-FNA is also a convenient method for evaluation of mediastinal lymph nodes. Its particular strength lies in the detection of lymph nodes in the lower mediastinum and the aortopulmonary window while the pretracheal and hilar nodes are out of reach because of the interposition of air from the large airways. [3] A systematic review and meta-analysis of 1201 patients from 18 studies who underwent EUS-FNA for NSCLC staging demonstrated that EUS has a sensitivity of 83% (95% confidence intervals, 78% to 87%). [4] Wallace et al. reported that EBUS-TBNA and EUS-FNA showed the same sensitivity (69%) and NPV (88%). [5] The combination of EBUS and EUS obtained a sensitivity of 93% and an NPV 97%. EBUS-TBNA is also a safe procedure and applied under local anesthesia and conscious sedation. In the review of Varela-Lema, [6] none of the studies reported serious complications and colleagues are asking whether we observe any particular cut off value of SUV max over PET CT among the 18 patients with proven malignancy. The answer of this question is not an end point of our article. But we turned back to our data and analyzed the SUV max of these 18 patients. The cut-off value of SUV max over PET CT is 5.4 in our study.

Thank you for your interest in our article.

   References Top

1.Mehta A, Madhavi K. Comments on the utility of endorbonchial ultrasound-guided transbronchial needle aspiration in mediastinal or hilar lymph node evaluation in extrathoracic malignancy: Benign or malignant? Ann Thorac Med 2013;8:128-129.   Back to cited text no. 1
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2.Parmaksiz ET, Caglayan B, Salepci B, Comert SS, Kiral N, Fidan A, et al. The utility of endorbonchial ultrasound - guided transbronchial needle aspiration in mediastinal or hilarlymphnode evaluation in extrathoracic malignancy: Benign or Malignant? Ann Thorac Med 2012;7:210-4.  Back to cited text no. 2
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3.Annema JT, Klaus FR. Endosonography for lung cancer staging: One scope fits all? Chest 2010;138;765-7.  Back to cited text no. 3
4.Micames CG, McCrory DC, Pavey DA, Jowell PS, Gress FG. Endoscopic ultrasound-guided fine-needle aspiration fornon-small cell lung cancer staging: A systematic review andmetaanalysis. Chest 2007;131:539-48.  Back to cited text no. 4
5.Wallace MB, Pascual JM, Raimondo M, Woodward TA, McComb BL, Crook JE, et al. Minimallyinvasive endoscopic staging of suspected lung cancer. JAMA 2008;299:540-6.  Back to cited text no. 5
6.Varela-Lema L, Fernández-Villar A, Ruano-Ravina A. Effectiveness and safety of endobronchial ultrasound-transbronchial needle aspiration: A systematic review. Eur Respir J 2009;33:1156-64.  Back to cited text no. 6


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