Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
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Year : 2015  |  Volume : 10  |  Issue : 4  |  Page : 263-268

Risk of obstructive sleep apnea among Saudis with chronic renal failure on hemodialysis

1 Sleep Medicine and Research Center, Department of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
2 Department of Statistics, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
3 Renal Unit, Department of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
4 Sleep Disorders Center, Department of Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia

Correspondence Address:
Siraj Omar Wali
Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah 80215, P.O. Box: 21589
Saudi Arabia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1817-1737.164300

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Aim: The prevalence of obstructive sleep apnea (OSA) in end-stage renal disease (ESRD) patients was reported to be 10-fold that in the general population. OSA can worsen the clinical symptoms and cardiovascular complications of ESRD. We aimed to investigate the prevalence of symptoms and risk of OSA among Saudi patients with ESRD. Settings And Design: This multi-center, cross-sectional study was conducted in Jeddah, Saudi Arabia, between June 2012 and September 2013. Methods: The prevalence of OSA was assessed using the Berlin questionnaire. The presence of daytime sleepiness was evaluated using the Epworth sleepiness scale. Data were also collected on the medical history, clinical, and laboratory findings of participants. Results: In all, 355 patients (61% male) were enrolled (mean age: 45.5 ± 15.4 years). The overall prevalence of high-risk of OSA was 44.2% (males, 47.3%; females, 44.8%; P = 0.65). The prevalence of excessive daytime sleepiness (EDS) was 74%. Controlling for age, gender and body mass index, multivariate analysis revealed that hypertension and hepatitis C infection were the only comorbidities significantly associated with OSA (odds ratio [OR]: 3.827 and 0.559; confidence interval [CI]: 2.120-6.906 and 0.324-0.964; P < 0.0001 and 0.036, respectively). OSA was also strongly associated with EDS (OR: 3.054; CI: 1.676-5.565; P < 0.0001). Conclusions: In Saudi Arabia, the risk of OSA is more common in ESRD patients than in the general population. OSA is strongly associated with EDS. Interestingly, a significant negative correlation between OSA and hepatitis C infection was noted, which warrants further investigation.

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