Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection

Ali H Hajeer; Hanan Balkhy; Sameera Johani; Mohammed Z Yousef; Yaseen Arabi

doi:10.4103/1817-1737.185756

Official publication of the Saudi Thoracic Society, affiliated to King Saud University

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ORIGINAL ARTICLE

Year : 2016 | Volume : 11 | Issue : 3 | Page : 211-213

Association of human leukocyte antigen class II alleles with severe Middle East respiratory syndrome-coronavirus infection

Ali H Hajeer¹, Hanan Balkhy², Sameera Johani³, Mohammed Z Yousef⁴, Yaseen Arabi⁵
¹ Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences; Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia
² Department of Infection Prevention and Control, King Saud bin Abdulaziz University for Health Science; King Abdullah International Medical Research Center, King Abdulaziz Medical City, 5Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia
³ Department of Pathology and Laboratory, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia
⁴ Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
⁵ King Abdullah International Medical Research Center, King Abdulaziz Medical City; Department of Intensive Care, King Abdulaziz Medical City, Riyadh, Saudi Arabia

Correspondence Address:
Ali H Hajeer
Department of Basic Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, P. O. Box: 3660 Riyadh 11481
Saudi Arabia

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/1817-1737.185756

Background: Middle East Respiratory Syndrome (MERS) is a disease of the lower respiratory tract and is characterized by high mortality. It is caused by a beta coronavirus (CoV) referred to as MERS-CoV. Majority of MERS-CoV cases have been reported from Saudi Arabia. Aim: We investigated the human leukocyte antigen (HLA) Class II alleles in patients with severe MERS who were admitted in our Intensive Care Unit. Methods: A total of 23 Saudi patients with severe MERS-CoV infection were typed for HLA class II, results were compared with those of 161 healthy controls. Results: Two HLA class II alleles were associated with the disease; HLA-DRB1*11:01 and DQB1*02:02, but not with the disease outcome. Conclusions: Our results suggest that the HLA-DRB1*11:01 and DQB1*02:02 may be associated with susceptibility to MERS.

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