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Year : 2018  |  Volume : 13  |  Issue : 1  |  Page : 62-63
Pulmonary consequences of hypothyroidism

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq

Date of Web Publication4-Jan-2018

Correspondence Address:
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/atm.ATM_276_17

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How to cite this article:
Al-Mendalawi MD. Pulmonary consequences of hypothyroidism. Ann Thorac Med 2018;13:62-3

How to cite this URL:
Al-Mendalawi MD. Pulmonary consequences of hypothyroidism. Ann Thorac Med [serial online] 2018 [cited 2023 Mar 22];13:62-3. Available from:


I have read with interest the case–control study by Sadek et al. on the pulmonary consequences of hypothyroidism in a cohort of Egyptian patients.[1] In the methodology, the authors employed spirometry to measure various components of pulmonary function tests (PFTs), namely, forced vital capacity (FVC), FVC%, forced expiratory volume in 1 s (FEV1s), FEV1s%, FEV1s/FVC, and forced expiratory flow (FEF25–75)%.[1] The authors found that FVC% and FEF25–75% were significantly reduced in the hypothyroid group (P = 0.014, P = 0.000, respectively)compared to the control group.[1] I presume that these findings ought to be cautiously interpreted. My presumption is based on the presence of the following methodological limitation. It is obvious that the evaluation of PFTs is usually done by examining the absolute values of various PFTs components, comparing them with predicted values, and examining the shape of the curves. Precise interpretation of PFTs in particular patients compared to the matched controls requires population-specific reference values (RVs). There are many population-specific RVs of PFTs.[2],[3] The authors did not state which RVs were employed in their study. To my knowledge, the only available Egyptian RVs based on age and height were constructed more than two decades ago for healthy nonsmokers female industrial workers,[4] and they are no more useful in the clinical field and researches. Since normal pulmonary function tends to be genetically, nutritionally, physiologically, environmentally, socioeconomically, and ethnically determined,[5] it is pivotal to construct new Egyptian population-specific prediction equations to establish RVs of PFTs. I presume that the employment of national RVs might change the Sadek et al's study results.

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   References Top

Sadek SH, Khalifa WA, Azoz AM. Pulmonary consequences of hypothyroidism. Ann Thorac Med 2017;12:204-8.  Back to cited text no. 1
[PUBMED]  [Full text]  
LaVange L, Davis SM, Hankinson J, Enright P, Wilson R, Barr RG, et al. Spirometry reference equations from the hispanic community health study/Study of latinos (HCHS/SOL). J Respir Crit Care Med 2017. [Epub ahead of print].  Back to cited text no. 2
Fawibe AE, Odeigah LO, Saka MJ. Reference equations for spirometric indices from a sample of the general adult population in Nigeria. BMC Pulm Med 2017;17:48.  Back to cited text no. 3
Faris R, Elgewaily M, Gadallah M, Abbas H, Elkholi F. Spirometric standards for healthy nonsmokers female industrial workers in Egypt. J Egypt Public Health Assoc 1990;65:37-47.  Back to cited text no. 4
Ruppel GL, Enright PL. Pulmonary function testing. Respir Care 2012;57:165-75.  Back to cited text no. 5


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