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LETTER TO THE EDITOR |
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| Year : 2019 | Volume
: 14
| Issue : 1 | Page : 99 |
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| Bone marrow micrometastasis in nonsmall cell lung cancer: A new prognostic marker? |
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Nikolaos Barbetakis1, Dimitrios Paliouras1, Nikolaos Diamantopoulos2
1 Department of Thoracic Surgery, Theagenio Cancer Hospital, Thessaloniki, Greece
2 Department of 1st Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece
| Date of Web Publication | 10-Jan-2019 |
Correspondence Address:
Nikolaos Barbetakis
Department of Thoracic Surgery, Theagenio Cancer Hospital, Thessaloniki
Greece
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/atm.ATM_225_18
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How to cite this article:
Barbetakis N, Paliouras D, Diamantopoulos N. Bone marrow micrometastasis in nonsmall cell lung cancer: A new prognostic marker?. Ann Thorac Med 2019;14:99 |
Sir,
We have read with great interest the article by Jazieh et al.,[1] and we have to congratulate them for their excellent work. The aim of our brief comment is to highlight the significance of molecular detection of isolated tumor cell in the bone marrow. This is highly associated with two findings, poor overall survival (OS) and an increased risk of disease recurrence.[2] It has to be mentioned that the presence of bone marrow micrometastasis in nonsmall cell lung cancer (NSCLC) is not associated with pathological types and tumor staging. Occult bone marrow invasion may represent a new prognostic marker in NSCLC and may help oncologists for the selection of patients for adjuvant therapy following surgery, or to avoid unnecessary operations.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
 References | |  |
| 1. | Jazieh AM, AlSumai TS, Ali YZ, Sheblaq NR, Alkaiyat M. The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study. Ann Thorac Med 2018;13:150-5.  [ PUBMED] [Full text] |
| 2. | Deng XF, Liu QX, Zhou D, Min JX, Dai JG. Bone marrow micrometastasis is associated with both disease recurrence and poor survival in surgical patients with node-negative non-small-cell lung cancer: A meta-analysis. Interact Cardiovasc Thorac Surg 2015;21:21-7. |
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