Annals of Thoracic Medicine Official publication of the Saudi Thoracic Society, affiliated to King Saud University
 
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BRIEF REPORT
Year : 2022  |  Volume : 17  |  Issue : 1  |  Page : 66-69

A COVID-19 family cluster with retinitis pigmentosa and hypogammaglobulinemia


1 Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah; College of Medicine, AlFaisal University, Riyadh, Kingdom of Saudi Arabia
2 Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah; Department of Infectious Diseases, Al Moosa Specialist Hospital, Al-Ahsa, Kingdom of Saudi Arabia
3 Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia
4 Department of Medicine, Al Nour Specialist Hospital, Makkah, Kingdom of Saudi Arabia
5 Department of Medicine, King Fahd General Hospital, Jeddah, Kingdom of Saudi Arabia
6 Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia
7 College of Medicine, AlFaisal University, Riyadh; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia

Correspondence Address:
Dr. Abeer N Alshukairi
Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, P. O. Box: 40047, Jeddah 21499
Kingdom of Saudi Arabia
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DOI: 10.4103/atm.atm_520_21

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Hypogammaglobulinemia is a heterogeneous group of innate and acquired antibody deficiency with variable disease severity, recurrent pneumonia, and bronchiectasis. The outcome of COVID in patients with hypogammaglobulinemia is variable depending on age, comorbidities, type of immunodeficiency, and use of immunoglobulins. We report the favorable outcome of two family members diagnosed with DNAJC17-related retinitis pigmentosa and hypogammaglobulinemia syndrome and infected with SARS-CoV-2 following contact with their mother who had COVID-19. We describe the different immune dysfunction in these patients and their impact on the course and management of SARS-CoV-2 infection.


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