Year : 2012 | Volume
: 7 | Issue : 2 | Page : 74--77
Interleukin-1 receptor antagonist gene polymorphism in patients with multidrug-resistant Acinetobacter baumannii-associated pneumonia
Min-Jer Hsu1, Yun-Chieh Lu1, Yu-Chang Hsu1, Wen-Sheng Liu2, Wen-Tung Wu3
1 Department of Pulmonary, Antai Tian, Sheng Memorial Hospital, Taiwan
2 Department of Biotechnology, Yung-Ta Institute of Technology and Commerce, Pingtung, Taiwan
3 Asia Pacific Biotech Developing, Inc., Kaohsiung, Taiwan
Objective: Multidrug-resistant Acinetobacter baumannii (MDRAB)-associated pneumonia has been a common disease and a therapeutic problem in hospitals. Interleukin-1 receptor antagonist (IL-1ra) has been considered a required role for host immune defense in pneumonia disease. The aim of this study was to investigate whether the variable nucleotide tandem repeat polymorphism of the IL-1ra gene was associated with MDRAB-related pneumonia.
Methods: Sixty-six pneumonia patients were enrolled in the study: 36 subjects had MDRAB-related pneumonia and 30 controls had non-MDRAB pneumonia. Polymerase chain reaction, restriction fragment length polymorphism, and agarose gel electrophoresis techniques were used to determine the IL-1ra genotype.
Results: The frequencies of the IL-1ra genotype in the MDRAB-related pneumonia cases were A1/A1, 0.889 and A1/A2, 0.111; the frequencies of the IL-1ra genotype in the controls were A1/A1, 0.333 and A1/A2, 0.667. A statistically significant difference was determined (P < 0.05). We also observed an increase in the frequency of IL-1ra A1 allele in the MDRAB-related pneumonia group. A statistically significant difference was determined (P<0.05).
Conclusions: We suggested that IL-1ra polymorphism was associated with the risk of MDRAB-related pneumonia.
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|How to cite this article:|
Hsu MJ, Lu YC, Hsu YC, Liu WS, Wu WT. Interleukin-1 receptor antagonist gene polymorphism in patients with multidrug-resistant Acinetobacter baumannii-associated pneumonia.Ann Thorac Med 2012;7:74-77
|How to cite this URL:|
Hsu MJ, Lu YC, Hsu YC, Liu WS, Wu WT. Interleukin-1 receptor antagonist gene polymorphism in patients with multidrug-resistant Acinetobacter baumannii-associated pneumonia. Ann Thorac Med [serial online] 2012 [cited 2022 Jul 7 ];7:74-77
Available from: https://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2012;volume=7;issue=2;spage=74;epage=77;aulast=Hsu;type=0