Annals of Thoracic Medicine
ORIGINAL ARTICLE
Year
: 2018  |  Volume : 13  |  Issue : 3  |  Page : 150--155

The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study


Abdulrahman M Jazieh, Thuraya S AlSumai, Yosra Z Ali, Nagham R Sheblaq, Mohammad Alkaiyat 
 King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences; Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia

Correspondence Address:
Dr. Thuraya S AlSumai
Department of Oncology, King Abdulaziz Medical City, National Guard Health Affairs, Riyadh 11426
Kingdom of Saudi Arabia

CONTEXT AND AIM: The skeleton is a frequent site for metastasis in patients with breast, lung, and prostate cancer. Bone metastasis compromises skeletal integrity leading to skeletal-related events (SREs). This study aims at estimating the prevalence of bone metastasis in lung cancer and describing types of bone involvement, management, outcomes, and overall survival. METHODS: We retrospectively reviewed the charts of 259 patients with nonsmall cell lung cancer who consulted the Department of Medical Oncology at our institution between January 2002 and December 2012. We documented their lung cancer characteristics, presence of skeletal metastases, management types, outcome parameters, and survival status. RESULTS: A total of 116 patients (58.6%) were diagnosed with bone metastasis. The most common site of metastasis was the spine. The most common SREs were bone pain (44%) and need for radiotherapy (25.9%). Patients with adenocarcinoma (P = 0.002) and concomitant liver metastasis (P = 0.013) tended to have more incidence of bone metastasis. Survival rates were (36%) at 1 year, and (3%) at 5 years. Metastasis to the bone did not impact patients' survival. Patients tended to have worse survival in the presence of concomitant bone and liver metastases (P = 0.012), older age (P = 0.024), lower limb metastasis (P = 0.014), hypercalcemia (P = 0.001), and not receiving calcium therapy (P = 0.011). CONCLUSION: Metastatic bone disease is considered a huge burden on patients, clinicians, and the society. The majority of bone metastasis patients will experience SREs. Most SREs predict poor prognosis. Supportive therapy to overcome the reasons for poor prognosis may improve patients' survival and quality of life.


How to cite this article:
Jazieh AM, AlSumai TS, Ali YZ, Sheblaq NR, Alkaiyat M. The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study.Ann Thorac Med 2018;13:150-155


How to cite this URL:
Jazieh AM, AlSumai TS, Ali YZ, Sheblaq NR, Alkaiyat M. The pattern of bone involvement, management, and outcomes in patients with nonsmall cell lung cancer: A retrospective study. Ann Thorac Med [serial online] 2018 [cited 2022 Oct 2 ];13:150-155
Available from: https://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2018;volume=13;issue=3;spage=150;epage=155;aulast=Jazieh;type=0