Year : 2019 | Volume
: 14 | Issue : 4 | Page : 269--277
Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring
Obianuju B Ozoh1, Olufunto O Kalejaiye1, Ojiebun E Eromesele3, Yusuf A Adelabu3, Sandra K Dede3, Folasade O Ogunlesi2
1 Department of Medicine, College of Medicine, University of Lagos; Department of Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria
2 Division of Pulmonary and Sleep Medicine, Children's National Health Systems; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
Background: Pulmonary complications of sickle cell disease (SCD) contribute to excess morbidity and mortality. The burden of pulmonary dysfunction among Nigerians with SCD has not been well elucidated.
OBJECTIVES: The objectives of this study are to describe the frequency and pattern of spirometry abnormalities in SCD and to explore the association between pulmonary dysfunction and selected parameters.
METHODS: A cross-sectional study among adolescents and adults with SCD attending a University Teaching Hospital and healthy age- and gender-matched controls. Respiratory symptoms, oxygen saturation, spirometry, complete blood counts, and fetal hemoglobin (Hb) were measured.
RESULTS: A total of 245 participants with SCD and 216 controls were included in the study. Frequency of respiratory symptoms was similar between the two groups. The median forced expiratory volume 1 (FEV1), forced vital capacity (FVC), and the FEV1/FVC were significantly lower in SCD as compared to controls (P = 0.000 in all instances). The frequency of abnormal pulmonary patterns was higher in SCD as compared to controls with abnormal spirometry pattern in 174 (71%) and 68 (31.5%) of participants with SCD and controls, respectively (P = 0.000). The suggestive of restrictive pattern was predominant (48% vs. 23%), but obstructive (11.8% vs. 7.4%) and mixed patterns (11% vs. 0.9%) were also found among SCD versus controls. Hb concentration was positively associated with FEV1 and FVC, whereas white cell count and age were negatively associated with FVC and FEV1, respectively.
CONCLUSION: There is a high burden of pulmonary dysfunction in SCD among Nigerians which may be related to the severity of disease. There is a need for further research to explore the effectiveness of potential interventions so as to harness the benefits from monitoring and early detection.
Dr. Obianuju B Ozoh
Department of Medicine, College of Medicine, University of Lagos, Lagos
|How to cite this article:|
Ozoh OB, Kalejaiye OO, Eromesele OE, Adelabu YA, Dede SK, Ogunlesi FO. Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring.Ann Thorac Med 2019;14:269-277
|How to cite this URL:|
Ozoh OB, Kalejaiye OO, Eromesele OE, Adelabu YA, Dede SK, Ogunlesi FO. Pulmonary dysfunction among adolescents and adults with sickle cell disease in Nigeria: Implications for monitoring. Ann Thorac Med [serial online] 2019 [cited 2023 Apr 2 ];14:269-277
Available from: https://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2019;volume=14;issue=4;spage=269;epage=277;aulast=Ozoh;type=0